ISSN:
1432-1041
Keywords:
Vasoconstriction
;
cyclosporin A
;
vascular smooth muscle cells
;
cytosolic free calcium
;
cell proliferation
;
phosphoinositide turnover
;
cyclosporin A-induced hypertension
;
PDGF
;
adverse effect
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Pretreatment of rat vascular smooth muscle cells with cyclosporin A caused concentration- and time-dependent enhancement of both angiotensin II- and platelet-derived growth factor-stimulated cellular functions, which may be related to a rise in vascular tone. In particular, cyclosporin A increased cytosolic free calcium, and augmented the agonist-induced formation of inositol polyphosphate. In addition, it markedly increased the sensitivity of the cells to platelet-derived growth factor-mediated stimulation of thymidine incorporation. The potentiation of vascular smooth muscle cell activity by cyclosporin A may be a novel mechanism by which it exerts an adverse vasoconstrictor effect.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00314955
