ISSN:
1573-0743
Keywords:
infarction
;
ischemia
;
mitochondrial function
;
triglyceride
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract BMIPP is a radioiodinated fatty acid analogue used for myocardial single photon emission CT (SPECT) imaging based on high cardiac fatty acid metabolism. In normal dogs, 74% of the injected BMIPP was instantly extracted and was then retained in 65.3%. The washout of the retained radioactivity was low, and most of the washout was alpha- and beta-oxidation metabolites. ATP concentration plays an important role in the myocardial uptake and retention of BMIPP. The ATP-dependent BMIPP uptake at the TG pool was strongly regulated by etomoxir with modifying mitochondrial β-oxidation and subsequent ATP production. Thus, myocardial viability was reflected on the BMIPP uptake in acute ischemia. In spite of in-significant changes in early extraction and retention, BMIPP back diffusion (r=−0.92) and full-oxidation metabolite (r=0.78) were correlated with the severity of ischemia. Mismatched region of BMIPP with flow (Tl-201) showed decreased metabolic enzymes such as citrate synthase and 3-hydroxyacyl-CoA dehydrogenase. These data suggest that BMIPP would be feasible for detecting cellular energy state from lipid metabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1006167713330
