ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A cytofluorometric method was used to measure the number of IgE receptors available for binding and the native IgE content on microscopically identified peritoneal mast cells of Sprague-Dawley rats aged 4 to 25 weeks. During this period of growth, the mast cells increased progressively in size, granule mass and histamine content, but the number of IgE receptors did not increase in relation to body weight or age, although it varied greatly within the mast cell populations of individual rats as well as between the different rats. The peritoneal mast cells of these normal, naive, specific pathogen-free rats raised under controlled conditions and without signs of infections, were found to carry a significant number of IgE molecules of unknown specificity. The IgE content varied greatly among the individual mast cells within a given population, but, on average, as much as 74% of the receptors available for binding were occupied.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01996469
