ISSN:
0959-8103
Keywords:
drug-delivery systems
;
poly(2-hydroxyethyl methacrylate)
;
poly(ethylene glycol)
;
diltiazem hydrochloride
;
reservoir-matrix systems
;
zero-order release kinetics
;
membrane barriers
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
,
Physics
Notes:
A new type of complex reservoir-matrix system for the controlled delivery of diltiazen hydrochloride was developed. This capsule-type device was designed for oral administration to humans and/or animals. It contained (i) an appropriate amount of the drug in a compartment; (ii) a swelling-controlled membrane which was prepared by mixing polymeric materials with another appropriate amount of the drug; and (iii) a water-soluble gelatin capsule as container. The swelling-controlled membranes were prepared from poly(2-hydroxyethyl methacrylate) hydrogels. The effect of pH on the swelling of the hydrogels was studied. In-vitro dissolution testing was carried out to evaluate the release of the drug using a continuous-flow method. Zero-order release kinetics was obtained over a period of 12 h.
Additional Material:
13 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/pi.1995.210380401
