ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A total synthesis of the antibiotic griseofulvin is described. Starting from phloroglucinol, rac. epi-griseofulvin could be synthesized. The latter was isomerized to rac. griseofulvin and hydrolysed to rac. griseofulvic acid by way of rac. iso-grisrofulvin. Resolution of rac. griseofulvic acid was achieved by means of brucine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19600430530