Keywords:
Gastrointestinal mucosa.
;
Electronic books.
Type of Medium:
Online Resource
Pages:
1 online resource (150 pages)
Edition:
1st ed.
ISBN:
9781615047352
Series Statement:
Colloquium Series on Integrated Systems Physiology: from Molecule to Function Series
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=4751326
Language:
English
Note:
Intro -- Regulation of Gastrointestinal Mucosal Growth -- Colloquium Digital Library of Life Sciences -- Colloquium Series on Integrated Systems Physiology: From Molecule to Function to Disease -- ABSTRACT -- Key Words -- Preface to the Second Edition -- Contents -- Chapter 1: Introduction -- Chapter 2: Intestinal Architecture and Development -- 2.1 Mucosal Wall Architecture -- 2.2 Development and Functions -- Chapter 3: Characteristics of Gut Mucosal Growth -- Chapter 4: Intestinal Stem Cells -- 4.1 ISCs and Their Niches -- 4.2 Cancer Stem Cells -- 4.3 Signaling Pathways Regulating ISCs -- Chapter 5: Role of GI Hormones on the Gut Mucosal Growth -- 5.1 Gastrin -- 5.2 CCK -- 5.3 Secretin -- 5.4 Somatostatin -- 5.5 Ghrelin -- 5.6 Neurotensin -- 5.7 Bombesin/GRP -- 5.8 Other GI Hormones -- Chapter 6: Peptide Growth Factors in GI Mucosal Growth -- 6.1 EGF Family -- 6.2 TGF-β Family -- 6.3 IGF Family -- 6.4 FGF Family -- 6.5 Other Factors -- Chapter 7: Luminal Nutrients and Microbes in Gut Mucosal Growth -- 7.1 Luminal Factors -- 7.2 Microbes in Health and Mucosal Growth -- 7.3 Dietary Supplements -- Chapter 8: Polyamines in the Regulation of Mucosal Growth -- 8.1 Polyamine Metabolism -- 8.2 Polyamines Stimulate Mucosal Growth by Enhancing Gene Transcription -- 8.2.1 Polyamines Regulate Epithelial Renewal by Altering Expression of Protooncogenes -- 8.2.2 Polyamines Are Required for Protooncogene Transcription -- 8.2.3 Possible Mechanisms of Action of the Polyamines -- 8.3 Induced mRNA Stabilization and Growth Arrest After Polyamine Depletion -- 8.3.1 Polyamine Depletion Stabilizes p53 -- 8.3.2 Polyamines Modulate JunD mRNA Stability -- 8.3.3 Polyamine Depletion Stabilizes TGF-β mRNA and Activates Smad Signaling -- 8.3.4 Polyamines Regulate Apoptosis by Altering the Stability of ATF-2 and XIAP mRNAs and Stress Gr.
,
8.4 Polyamines Modulate the Stability of mRNAs via the RNA-binding Protein HuR -- 8.4.1 Polyamines Modulate Subcellular Trafficking of HuR -- 8.4.2 Induced Cytoplasmic HuR Binds to Target mRNAs in Polyamine-Deficient Cells -- 8.4.3 Induced HuR Stabilizes its Target mRNAs in Polyamine-Deficient Cells -- 8.5 mRNA Translation by Polyamines -- Chapter 9: Noncoding RNAs in Gut Mucosal Growth and Epithelium Integrity -- 9.1 miRNAs in Gut Mucosal Growth and homeostasis -- 9.1.1 miR-222 -- 9.1.2 miR-29b -- 9.1.3 miR-503 -- 9.1.4 miR-195 -- 9.1.5 miR-122a and Others -- 9.2 LncRNAs in Gut Mucosal Integrity -- 9.2.1 LncRNA H19 -- 9.2.2 LncRNA SPRY4-IT1 -- Summary and Conclusions -- Acknowledgments -- References -- Author Biographies.
