Keywords:
Gonadotropin-Releasing Hormone - physiology.
;
Electronic books.
Type of Medium:
Online Resource
Pages:
1 online resource (396 pages)
Edition:
1st ed.
ISBN:
9781119159452
Series Statement:
Wiley-INF Masterclass in Neuroendocrinology Series
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=4432166
DDC:
612.8
Language:
English
Note:
Intro -- Title Page -- Copyright -- Table of Contents -- List of Contributors -- Series Preface -- Preface -- About the Companion Website -- Chapter 1: Bridging Between Experiments and Equations: A Tutorial on Modeling Excitability -- 1.1 Introducing excitability -- 1.2 Introducing the Morris-Lecar model -- 1.3 Opening XPP and triggering an action potential -- 1.4 Action potentials in the phase plane -- 1.5 Model response to sustained current injection -- 1.6 Reading a bifurcation diagram -- 1.7 Saddle node on an invariant circle (SNIC) bifurcation -- 1.8 Time-scale separation -- 1.9 Homoclinic bifurcation -- 1.10 Bursting -- 1.11 Eigenvalues and stability -- 1.12 Perspectives -- Acknowledgement -- References -- Chapter 2: Ion Channels and Electrical Activity in Pituitary Cells: A Modeling Perspective -- 2.1 Endocrine pituitary cells are electrically active -- 2.2 Endocrine pituitary cell types -- 2.3 Voltage-gated ion channels -- 2.4 Nonselective cation channels -- 2.5 Ligand-gated ion channels -- 2.6 Spontaneous electrical activity and ca2+ signalling -- 2.7 Modulation of spontaneous electrical activity by GPCRs -- 2.8 The dynamic clamp technique for studying the contributions of ion channels to electrical activity -- 2.9 Perspectives -- Recommended reading -- Chapter 3: Endoplasmic Reticulum- and Plasma-Membrane-Driven Calcium Oscillations -- 3.1 Introduction -- 3.2 Calcium balance equations -- 3.3 ER-driven calcium oscillations -- 3.4 Combining ER and PM oscillators -- 3.5 The road goes ever on -- 3.6 Conclusions -- Acknowledgments -- References -- Chapter 4: A Mathematical Model of Gonadotropin-Releasing Hormone Neurons -- 4.1 Introduction -- 4.2 Previous models of GnRH neurons -- 4.3 A model of GnRH neurons in hypothalamic slices -- 4.4 Model results -- 4.5 Conclusions and future work -- 4.6 Appendix: the model equations and parameters.
,
References -- Chapter 5: Modeling Spiking and Secretion in the Magnocellular Vasopressin Neuron -- 5.1 Background -- 5.2 Modeling -- 5.3 Bursting in a spiking model -- 5.4 Modeling spike-triggered secretion -- 5.5 Population modeling -- 5.6 Conclusion -- References -- Further Reading -- Chapter 6: Modeling Endocrine Cell Network Topology -- 6.1 Introduction -- 6.2 Networks -- 6.3 Step-by-step experimental and analytical protocol -- 6.4 Worked example -- 6.5 Perspectives -- Further reading -- References -- Chapter 7: Modeling the Milk-Ejection Reflex -- 7.1 The milk-ejection reflex -- 7.2 The Model -- 7.3 Building the model -- 7.4 Model behavior -- 7.5 Discussion -- 7.6 Perspectives -- Bibliography -- Chapter 8: Dynamics of the HPA Axis: A Systems Modeling Approach -- 8.1 Introduction -- 8.2 Mathematically modeling the HPA axis -- 8.3 Unveiling the mechanism of ultradian pulsatility -- 8.4 Exploring model predictions experimentally -- 8.5 Significance of ultradian pulsatility for stress responsiveness -- 8.6 Discussion -- 8.7 Perspectives -- References -- Chapter 9: Modeling the Dynamics of Gonadotropin-Releasing Hormone (GnRH) Secretion in the Course of an Ovarian Cycle -- 9.1 Introduction -- 9.2 A single dynamical framework for the control of the GnRH pulse and surge generator by ovarian steroids -- 9.3 GnRH secretion pattern along an ovarian cycle -- 9.4 Reproducing known effects of ovarian steroids on the surge -- 9.5 Steroid challenges in the pulsatile regime -- 9.6 Conclusion -- References -- Glossary -- Index -- End User License Agreement.
