Keywords:
Aquaporins.
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Electronic books.
Description / Table of Contents:
Aquaporins summarizes the present knowledge in this expanding field of research, starting with the structural analysis of water channel proteins. Subsequent chapters begin with mammalian aquaporins, examining physiology and pathophysiology, analysis of knock-out model animals, and the regulation of aquaporin function. Also covered is the distribution and regulation of aquaporins in plants and the function of water and glycerol channels in microbial systems. Comprehensive treatment of a topical research field Authored by world leaders in the field Covers structural biology and physiology Covers different experimental and biological systems Chapters on plant and microbial systems Extensive treatment of mammalian physiology and pathophysiology Structural analysis excellently illustrated.
Type of Medium:
Online Resource
Pages:
1 online resource (408 pages)
Edition:
1st ed.
ISBN:
9780080494395
Series Statement:
Issn Series ; v.Volume 51
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=296899
DDC:
572.6
Language:
English
Note:
Front Cover -- Aquaporins -- Copyright Page -- Contents -- Contributors -- Preface -- Previous Volumes In Series -- Chapter 1. Discovery of the Aquaporins and Their Impact on Basic and Clinical Physiology -- I. Pre-Aquaporin Era -- II. The First Recognized Water Channel Protein -- III. Other Mammalian Aquaporins -- IV. Nonmammalian Homologs -- V. Perspective -- References -- Chapter 2. The Aquaporin Superfamily: Structure and Function -- I. Introduction -- II. Two-Dimensional Crystallization of Membrane Proteins -- III. Electron Crystallography -- IV. Atomic Force Microscopy -- V. AQP1, The Erythrocyte Water Channel -- VI. AQP0: The Major Intrinsic Protein of Lens Fiber Cells -- VII. Water Channel of Escherichia Coli: Aqpz -- VIII. Glycerol Channel of Escherichia Coli: Glpf -- IX. Comparison of the High-Resolution Projection Structures of Glpf and AQP1 -- X. Conclusion and Perspectives -- References -- Chapter 3. Physiological Roles of Aquaporins in the Kidney -- I. Introduction -- II. Water Transport along The Renal Tubule -- III. Water Permeability along the Renal Tubule -- IV. Aquaporin-1 Facilitates Isoosmotic Fluid Transport in Proximal Tubule -- V. Aquaporin-1 Allows Osmotic Equilibration In the Thin Descending Limb Of Henle Despite Rapid Flow Of Tubule Fluid -- VI. Aquaporin-1 Allows Osmotic Equilibration in the Descending Vasa Recta -- VII. Aquaporins Provide Molecular Targets For Regulation of Water Transport in the Renal Collecting Duct -- References -- Chapter 4. Pathophysiology of Renal Aquaporins -- I. Introduction -- II. Pathophysiology of Renal Aquaporins -- III. Inherited NDI and CDI -- IV. Acquired NDI -- V. Urinary Concentrating Defects -- VI. States of Water Retention -- VII. Conclusions -- References -- Chapter 5. Genetic and Biophysical Approaches to Study Water Channel Biology -- I. Introduction.
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II. Lessons from Aquaporin Knockout Mice -- III. Biophysical Analysis of Aquaporin Function -- IV. Aquaporin Structure and Function -- V. New Directions in Aquaporin Physiology and Biophysics -- References -- Chapter 6. Trafficking of Native and Mutant Mammalian MIP Proteins -- I. Normal Routing of MIP Proteins -- II. Disturbed Trafficking of MIP Proteins -- References -- Chapter 7. Aquaporins Of Plants: Structure, Function, Regulation, and Role in Plant Water Relations -- I. The Transpiration Stream -- II. Water Movement in and Between Living Tissues -- III. Molecular Characteristics and Transport Properties Of Plant Aquaporins -- IV. Subcellular Location of Plant Aquaporins -- V. What Do The Water and Solute Transport Properties Of Membranes Tell Us about the Aquaporins In Those Membranes? -- VI. The Multiple Roles of Aquaporins: How to Link Water Transport Properties to Functions at the Cellular and Tissue Level -- VII. Regulation of Aquaporin Expression and Water Transport Activity -- References -- Chapter 8. Microbial Water Channels and Glycerol Facilitators -- I. Introduction -- II. Microbial Aquaporins and Glycerol Facilitators -- III. Transport Properties and Channel Selectivity of Microbial MIP Channels -- IV. From Primary to Quaternary Structure in Microbial MIPs -- V. Physiological Roles -- VI. Microbial MIP Channels in Osmoregulation -- VII. Control of the Function of Microbial MIP Channels -- VIII. Conclusions and Future Perspectives -- References -- Chapter 9. Future Directions Of Aquaporin Research -- I. Identification And Characterization of New MIP Channels -- II. Why Have So Many MIP Channels? -- III. Analysis of the Physiological Roles of Aquaporins -- IV. Structure and Function -- V. Aquaporins as Targets for Treatment of Human Disease -- VI. Aquaporins as Possible Targets for Genetic Engineering and Crop Improvement.
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VII. Metabolic Engineering With Aquaporins -- VIII. The Aquaporin Research Community -- References -- Index.
