Note: Front Cover -- Microsomes and Drug Oxidations -- Copyright Page -- Table of Contents -- Participants -- Preface -- PART I: MORPHOLOGICAL AND BIOCHEMICAL CHARACTERISTICS OF MICROSOMES -- CHAPTER 1. MICROSOMES, ENDOPLASMIC RETICULUM AND INTERACTIONS OF CYTOPLASMIC MEMBRANES -- Introduction -- Properties of Lipid and Biological Membranes -- Endoplasmic Reticulum -- Peroxisomes and Smooth E.R. -- Synthesis and Transport of Lipoprotein Granules -- Smooth Endoplasmic Reticulum and Golgi Apparatus -- References -- CHAPTER 2. SUBFRACTIONATION OF RAT LIVER MICROSOMES -- Abstract -- Introduction -- Discussion -- Acknowledgement -- References -- CHAPTER 3. A POSSIBLE ROLE OF THE ENDOPLASMIC RETICULUM IN THE REGULATION OF GENETIC EXPRESSION THE MEMBRON CONCEPT -- References -- CHAPTER 4. THE METABOLISM OF DRUGS BY SUBFRACTIONS OF HEPATIC MICROSOMES: THE CASE FOR MICROSOMAL HETEROGENEITY -- Conclusion -- References -- PART II: ELECTRON TRANSFER COMPONENTS -- CHAPTER 5. ORGANIZATION OF THE MICROSOMAL ELECTRON TRANSPORT SYSTEM -- Discussion -- References -- Discussion -- CHAPTER 6. CHARACTERIZATION OF TWO HEMOPROTEINS OF LIVER MICROSOMES -- Spectral Properties of P-450 -- Concluding Remarks -- Acknowledgment -- References -- Discussion -- CHAPTER 7. CYTOCHROME P-450 REDUCTION IN LIVER MICROSOMES AND ITS RELATIONSHIP TO DRUG METABOLISM -- Reduction of azo- and nitro- and tetrazolium compounds -- Distribution of NADPH-dependent enzyme activities in microsomal subfractions -- Role of Various Components of the Electron Transfer Systemin Species Variation in Hepatic Microsomal Drug Metabolism -- Effect of Drug Substrates on Hepatic Microsomal Cytochrome P-450 Reduction by NADPH -- References -- Discussion -- CHAPTER 8. FATTY ACID ω - OXIDATION IN A SOLUBLE MICROSOMAL ENZYME SYSTEM CONTAINING P-450 -- Hemoprotein P-450 -- References -- Discussion. , CHAPTER 9. ENZYMATIC ω -OXIDATION: STOICHIOMETRY OF THE REACTION CATALYZED BY THE INDUCIBLE ENZYME SYSTEM OF PSEUDOMONAS OLEOVORANS -- References -- CHAPTER 10. THE PROPERTIES OF A PURIFIED HEPATIC MICROSOMAL MIXED FUNCTION AMINE OXIDASE -- Introduction -- Experimental -- Discussion -- References -- CHAPTER 11. A COMPARISON OF NADPH DEPENDENT REDUCTIVE CLEAVAGE AND N-DEMETHYLATION OF AMINOAZOBENZENE, MONOMETHYLAMINOAZO-BENZENE AND DIMETHYLAMINOAZOBENZENE BY CELL FREE PREPARATIONS FROM RAT LIVER -- Results -- Discussion -- References -- CHAPTER 12. OXYGEN REACTIONS IN MODEL SYSTEMS -- References -- CHAPTER 13. SIGNIFICANCE OF THE NIH SHIFT WITH RESPECT TO LIVER MICROSOME HYDROXYLATIONS -- References -- Discussion -- CHAPTER 14. THE MICROSOMAL HYDROXYLATION OF ETHYLBENZENE STEREOCHEMICAL, INDUCTION AND ISOTOPIC STUDIES -- Discussion -- Acknowledgements -- References -- PART III: ALTERATIONS OF MICROSOMAL ENZYMES -- CHAPTER 15. OVERALL BIOCHEMICAL EFFECTS OF DRUG INDUCTION ON LIVER MICROSOMES -- Acknowledgment -- References -- Discussion -- CHAPTER 16. SPECIFICITY IN THE REGULATION OF THE 6β- , 7α AND 16α-HYDROXYLATION OF TESTOSTERONE BY RAT LIVER MICROSOMES -- Results -- Summary -- Acknowledgments -- References -- Discussion -- CHAPTER 17. FORMATION OF A NEW P-450 HEMOPROTEIN AFTER TREATMENT OF RATS WITH POLYCYCLIC HYDROCARBONS -- SKF 525-A Studies -- Two-Substrate Kinetic Studies -- Spectral Studies -- Binding Studies -- Thioacetamide Studies -- Summary -- Acknowledgement -- References -- Discussion -- CHAPTER 18. SPECTROPHOTOMETRIC STUDIES OF CYTOCHROME P-450 OF LIVER MICROSOMES AFTER INDUCTION WITH PHENOBARBITAL AND 3-METHYLCHOLANTHRENE -- References -- Discussion -- CHAPTER 19. THE EFFECTS OF 3-METHYLCHOLANTHRENE AND PHENOBARBITAL ON LIVER MICROSOMAL HEMOPROTEINS AND ON THE HYDROXYLATION OF BENZPYRENE -- Discussion -- References -- Discussion. , CHAPTER 20. SPECTRAL INVESTIGATIONS ON CYTOCHROME-P-450 -- References -- Discussion -- PART IV: DRUGS AND PROTEIN SYNTHESIS -- CHAPTER 21. DRUGS AND MICROSOMAL ENZYME FORMATION IN VIVO AND IN MAMMALIAN CELL CULTURE -- References -- Discussion -- CHAPTER 22. ACTIVATION OF CHROMATIN BY 3-METHYLCHOLANTHRENE -- Introduction -- Discussion -- Acknowledgements -- References -- Discussion -- CHAPTER 23. INDUCTION, STABILIZATION AND TURNOVER OF ENDOPLASMIC RETICULUM PROTEINS -- Summary -- References -- Discussion -- CHAPTER 24. EFFECT OF PHENOBARBITAL ON THE TURNOVER OF MICROSOMAL ENZYMES -- Methods -- Results and Discussions -- References -- Discussion -- CHAPTER 25. THE ROLE OF HEME IN THE SYNTHESIS AND REPRESSION OF MICROSOMAL PROTEIN -- Methods -- Results and Discussion -- Acknowledgement -- References -- Discussion -- CHAPTER 26. INSECT MICROSOMES AND INSECTICIDE CHEMICAL OXIDATIONS -- Introduction -- Resistance -- Summary -- Acknowledgement -- References -- Discussion -- CHAPTER 27. STIMULATORY EFFECT OF ACETONE ON THE ACTIVITY OF MICROSOMAL ANILINE PARA-HYDROXYLASE -- Summary -- Introduction -- Materials and Methods -- Results -- Discussion -- References -- SUBJECT INDEX.