Publication Date:
2018-10-30
Description:
Identification of a cellularly active SIRT6 allosteric activator Identification of a cellularly active SIRT6 allosteric activator, Published online: 29 October 2018; doi:10.1038/s41589-018-0150-0 The use of an allosteric drug-design method resulted in the identification of a first-in-class cellularly active SIRT6 activator that induces cell-cycle arrest in the G0–G1 phase, thus suppressing proliferation in human hepatocellular carcinoma cells.
Print ISSN:
1552-4450
Electronic ISSN:
1552-4469
Topics:
Biology
,
Chemistry and Pharmacology