Publication Date:
2018-07-19
Description:
The solute carrier SLC9C1 is a Na + /H + -exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding The solute carrier SLC9C1 is a Na〈sup〉+〈/sup〉/H〈sup〉+〈/sup〉-exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding, Published online: 18 July 2018; doi:10.1038/s41467-018-05253-x The sperm-specific solute carrier SLC9C1 is a phylogenetic chimaera that carries a voltage-sensing (VSD) and a cyclic nucleotide-binding domain (CNBD). Here authors show by electrophysiology and fluorimetry that SLC9C1 is a genuine Na+/H+ exchanger gated by voltage and cAMP.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics