Description: Deep underground mines are highly energy consuming due to the need to overcome the growing airflow resistance. The multi-fan station ventilation system (MFSVS), formed by several parallel fans at different locations in an underground mine generally, has greatly reduced energy costs by using high-quantity and low-pressure energy-saving fans. However, experimental data still indicates that 30–70% of the fan pressure is used to overcome the severe shock losses in a parallel fan station (PFS), in spite of more than 80% operating efficiency, and the shock losses greatly weaken the superiority and the service capacity of PFS. Based on the investigation and measured data of several PFSs in a MFSVS in an underground mine, a three-dimensional PFS model was developed by computational fluid dynamics (CFD) to demonstrate airflow performance and variation characteristics of velocity, pressure and turbulence. First, the fan characteristic in the PFS was discussed and compared with the fan operating performance under standard conditions; the shock losses were then presented from both sides of the inlet shock losses and the outlet shock losses in the PFS; meanwhile, the effects of blade angle variation and airflow mutual interference were conducted to determine whether they exert a significant influence on the shock losses. The results show that the shock losses are primarily generated in the range of 0 to 3.0 m from the fans’ exits, due to the intensely change in air velocity in the PFS. The study also provides several directions and references for recovering air pressure and reducing energy consumption in the parallel fans’ structure.