Publication Date:
2015-01-26
Description:
Aims Pseudoepitheliomatous hyperplasia (PEH) is defined as a pattern of epidermal reaction. However, it has not yet been extensively documented in extranodal NK/T cell lymphoma (ENKTL). The aim of our study was to analyze a series of ENKTL concomitant with PEH mimicking squamous cell carcinoma (SCC). Methods and results Our present study analyzed 34 cases of ENKTL concomitant with PEH. In our study, the incidence of PEH was noted as 3.8% in ENKTL diagnosed over a 13-year period. All 34 cases presented with PEH, appearing as tongue-like projections of squamous epithelium into the underlying submucosa/dermis with variable depth and jagged borders. The keratinocytes may exhibit a minor degree of cytological atypia, mostly in the stratum basale, and keratinocyte necrosis was absent. Atypical mitoses and a high nuclear-cytoplasmic ratio were absent. The submucosa and the squamous cell cords are permeated by atypical lymphocytes as well. Conclusions ENKTL can be associated with PEH, and the atypical lymphoid cell population can be highly subtle, which may be easily mistaken for SCC and leads to improper therapy. A correct diagnosis requires awareness and recognition of this pitfall by recognizing the associated conditions listed above, which distinguish PEH from SCC. This article is protected by copyright. All rights reserved.
Print ISSN:
0309-0167
Electronic ISSN:
1365-2559
Topics:
Medicine
