Publication Date:
2014-12-26
Description:
Publication date: Available online 23 December 2014 Source: FEBS Letters Author(s): Marina R. Amaiden , Verónica S. Santander , Noelia E. Monesterolo , Ayelen D. Nigra , Juan F. Rivelli , Alexis N. Campetelli , Juan Pie , Cesar H. Casale Formation of tubulin/Na + ,K + -ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. Moreover, we report a reduced content and activity of the enzyme tubulin tyrosine ligase in erythrocytes of hypertensive subjects. Such alterations are related to changes in erythrocyte deformability. Our findings indicate that the detyrosination/tyrosination cycle of tubulin is important in regulation of NKA activity, and that abnormalities in this cycle are involved in hypertension development.
Print ISSN:
0014-5793
Electronic ISSN:
1873-3468
Topics:
Biology
,
Chemistry and Pharmacology
,
Physics
