Publication Date:
2014-12-24
Description:
Tuberculosis remains a major health problem due to the emergence of drug-resistant strains of Mycobacterium tuberculosis . Some models have provided valuable information about drug resistance and efficacy; however, the translation of these results into effective human treatments has mostly proven unsuccessful. In this study, we adapted high-content screening (HCS) technology to investigate the activities of antitubercular compounds in the context of an in vitro granuloma model. We observed significant shifts in the MIC 50 s between the activities of the compounds under extracellular and granuloma conditions.
Print ISSN:
0066-4804
Electronic ISSN:
1098-6596
Topics:
Biology
,
Medicine