Publication Date:
2012-06-16
Description:
Background: The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy. Results: The extract of Cinnamomum zeylanicu against Escherichia coli ATCC 8739 and AG100 strains showed the best activities, with the lowest minimal inhibitory concentration (MIC) of 64 ¿g/ml. The extract of Dorstenia psilurus was the most active when tested in the presence of an efflux pump inhibitor, phenylalanine Arginine-ß- Naphtylamide (PAßN), a synergistic effect being observed in 56.25 % of the tested bacteria when it was combined with Erythromycin (ERY). Conclusion: The present work evidently provides information on the role of some Cameroonian spices in the fight against multi-resistant bacteria.
Electronic ISSN:
1756-0500
Topics:
Biology
,
Medicine