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Radiochemical and biological characterization of 99m Tc-oxiracetam as a model for brain imaging (2018)

Springer

In: Radiochemistry

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Publikationsdatum: 2018-03-06

Beschreibung: 99 m Tc-oxiracetam was prepared. It can be used as a radiotracer for brain imaging. Under the optimum conditions (0.5 mg of oxiracetam, 50 μg of SnCl 2 ·2H 2 O, pH 7, room temperature, 30 min), the radio-chemical yield determined by chromatographic methods reached 96%. Biodistribution studies with mice showed that the brain uptake of the complex was 5.1% injected dose per gram (% ID/g) at 5 min post injection. In this parameter, the complex surpasses the commercially available 99 m Tc-ECD (4.7% ID/g) and 99 m Tc-HMPAO (2.25% ID/g).

Print ISSN: 1066-3622

Digitale ISSN: 1608-3288

Thema: Chemie und Pharmazie

Publiziert von Springer

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