In:
PeerJ, PeerJ, Vol. 11 ( 2023-07-26), p. e15532-
Abstract:
Rheumatoid arthritis causes irreparable damage to joints. The present research sought to check fustin’s anti-arthritic efficacy against the complete Freund’s adjuvant-induced arthritis paradigm in animals by altering the inflammatory response. In the rats, complete Freund’s adjuvant was used to trigger arthritis and they received fustin at 50 and 100 mg/kg for 21 days. At regular intervals, the hind paw volume and arthritic score were assessed. After the trial period, hematological, antioxidant, pro-inflammatory cytokines, and other biochemical parameters were estimated. Fustin-treated rats showed the down-regulation of hind paw volume, arthritic score, and altered hematological parameters (TLC, DLC (neutrophil, lymphocyte, monocyte, eosinophil, basophil)). Furthermore, fustin significantly mitigates proinflammatory cytokine (reduced interleukin, tumor necrosis factor-a (TNF- α ), IL-6, IL-1 β ), oxidative stress (attenuated malondialdehyde (MDA), catalase (CAT), glutathione (GSH), superoxide dismutase (SOD)), attenuated production of prostaglandin E2 and myeloperoxidase (MPO) and improved nuclear factor erythroid 2-related factor (Nrf2) action. Fustin led to the benefit in arthritis-prone animals elicited by complete Freund’s adjuvant via pro-inflammatory cytokine.
Type of Medium:
Online Resource
ISSN:
2167-8359
DOI:
10.7717/peerj.15532/fig-1
DOI:
10.7717/peerj.15532/fig-2
DOI:
10.7717/peerj.15532/fig-3
DOI:
10.7717/peerj.15532/fig-4
DOI:
10.7717/peerj.15532/fig-5
DOI:
10.7717/peerj.15532/fig-6
DOI:
10.7717/peerj.15532/supp-1
DOI:
10.7717/peerj.15532/supp-2
Language:
English
Publisher:
PeerJ
Publication Date:
2023
detail.hit.zdb_id:
2703241-3