In:
eLife, eLife Sciences Publications, Ltd, Vol. 5 ( 2016-11-29)
Abstract:
SATB2 is a risk locus for schizophrenia and encodes a DNA-binding protein that regulates higher-order chromatin configuration. In the adult brain Satb2 is almost exclusively expressed in pyramidal neurons of two brain regions important for memory formation, the cerebral cortex and the CA1-hippocampal field. Here we show that Satb2 is required for key hippocampal functions since deletion of Satb2 from the adult mouse forebrain prevents the stabilization of synaptic long-term potentiation and markedly impairs long-term fear and object discrimination memory. At the molecular level, we find that synaptic activity and BDNF up-regulate Satb2, which itself binds to the promoters of coding and non-coding genes. Satb2 controls the hippocampal levels of a large cohort of miRNAs, many of which are implicated in synaptic plasticity and memory formation. Together, our findings demonstrate that Satb2 is critically involved in long-term plasticity processes in the adult forebrain that underlie the consolidation and stabilization of context-linked memory.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.17361.001
DOI:
10.7554/eLife.17361.002
DOI:
10.7554/eLife.17361.003
DOI:
10.7554/eLife.17361.004
DOI:
10.7554/eLife.17361.005
DOI:
10.7554/eLife.17361.006
DOI:
10.7554/eLife.17361.007
DOI:
10.7554/eLife.17361.008
DOI:
10.7554/eLife.17361.009
DOI:
10.7554/eLife.17361.010
DOI:
10.7554/eLife.17361.011
DOI:
10.7554/eLife.17361.012
DOI:
10.7554/eLife.17361.013
DOI:
10.7554/eLife.17361.014
DOI:
10.7554/eLife.17361.015
DOI:
10.7554/eLife.17361.016
DOI:
10.7554/eLife.17361.017
DOI:
10.7554/eLife.17361.018
DOI:
10.7554/eLife.17361.019
DOI:
10.7554/eLife.17361.020
DOI:
10.7554/eLife.17361.021
DOI:
10.7554/eLife.17361.022
DOI:
10.7554/eLife.17361.023
DOI:
10.7554/eLife.17361.024
DOI:
10.7554/eLife.17361.025
DOI:
10.7554/eLife.17361.026
DOI:
10.7554/eLife.17361.027
DOI:
10.7554/eLife.17361.039
DOI:
10.7554/eLife.17361.040
DOI:
10.7554/eLife.17361.028
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2016
detail.hit.zdb_id:
2687154-3