In:
Биомедицинска истраживања, Univerzitet u Istočnom Sarajevu, Medicinski fakultet Foča, Vol. 1, No. 1 ( 2010-12-28), p. 13-19
Abstract:
& lt;p & gt; & lt;strong & gt;Introduction. & lt;/strong & gt;The Bcl-2 gene codes an oncoprotein, inhibits a programmed cell death or apoptosis and it plays a very important role in colorectal cancerogenesis. The aim of our study is to determine Bcl-2 expression in colorectal carcinomas in relation with the stage of disease, histology of tumor type, localization and macroscopic growth pattern. & lt;strong & gt;Methods. & lt;/strong & gt; Immunohistochemichal detection of Bcl-2 protein expression was carried out on 90 resected colorectal carcinomas. The patients were divided into three groups according to the degree of Bcl-2 expression in a tumor: group 0 - there were no cells with positive immunohistochemical reaction; group I- up to 20 % of positive cells, and group II- above 20% of positive cells. The groups were compared in relation to the stage of disease, T stage of local spread of disease, histology of tumor type, localization and macroscopic growth pattern. & lt;strong & gt;Results. & lt;/strong & gt; 58% of patients at the second stage of disease had no expression of Bcl-2. Higher percentage (61%) of the patients with metastases ( stages III and IV) had high level of Bcl-2 expression. Tumors with polipoid growth pattern have higher level of Bcl-2 expression. & lt;strong & gt;Conclusion. & lt;/strong & gt;There is a statisticaly significant difference in Bcl-2 protein expression in patients surgically treated at the II and III stage of disease, stage T3a/b, T3c/d of local spread of disease and tumors whith polipoid growth pattern in relation to infiltrative growth pattern. & lt;/p & gt;
Type of Medium:
Online Resource
ISSN:
1986-8537
,
1986-8529
DOI:
10.59137/BII201001313B
Language:
English
Publisher:
Univerzitet u Istočnom Sarajevu, Medicinski fakultet Foča
Publication Date:
2010
