In:
Archives of Medical Science, Termedia Sp. z.o.o.
Abstract:
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown etiology which causes progressive deterioration
of the joints, leading to severe pain and functional disability. Vitamin D and its receptor (VDR) play a significant part in the onset of autoimmune diseases such as RA. The purpose of this study was to evaluate the association
between VDR gene polymorphisms and risk of developing RA. Material and methods A retrospective study was performed, including
214 RA cases and 748 controls of Caucasian origin. FokI (rs2228570), BsmI (rs1544410), TaqI (rs731236), ApaI (rs7975232) and Cdx2 (rs11568820) gene
polymorphisms were analyzed by TaqMan Results The recessive logistic regression model showed that the VDR FokIAA genotype was associated with lower risk of RA (p = 0.0255; OR = 0.58;
95% CI: 0.35–0.92). No other genetic polymorphism showed any association with RA in any of the models tested. Haplotype analysis revealed that the haplotypes ACGAG (p = 0.033; OR = 1.62; 95% CI: 1.04–2.53) and GTGCA
(p 〈 0.01; OR = 2.77; 95% CI: 1.53–4.98) for BsmI, Cdx2, FokI, ApaI and TaqI
were associated with higher risk of RA. Conclusions VDR FokI gene polymorphism showed a trend for risk of RA,
taking into account the variables of gender, age and tobacco use, and preventing false positives. Among our patients we found no influence of VDR BsmI, TaqI, ApaI and Cdx2 on the risk of developing RA. However, haplotype
analysis indicated that the haplotypes ACGAG and GTGCA were associated with higher risk of RA.
Type of Medium:
Online Resource
ISSN:
1734-1922
,
1896-9151
Language:
Unknown
Publisher:
Termedia Sp. z.o.o.
Publication Date:
2021
detail.hit.zdb_id:
2203781-0
