In:
Future Science OA, Future Science Ltd, Vol. 2, No. 1 ( 2016-03)
Abstract:
Lay Abstract: In the last few years it has become clear that oropharyngeal carcinomas can be caused by an HPV infection. Overall, HPV+ carcinomas have a better outcome. Recent studies suggest that could be partly explained by immune cells in the tumor's microenvironment of HPV+ carcinomas. Following a systematic review of the literature focusing on immunological difference between HPV+ and HPV- oropharyngeal cancers, we found a survival benefit associated with increase in immune cells in both HPV+ and HPV-. We found an increase in CD8+ lymphocytes primarily in HPV+ carcinomas. Our review underscores the role of the immune system in the biological and clinical behavior of these cancers.
Type of Medium:
Online Resource
ISSN:
2056-5623
Language:
English
Publisher:
Future Science Ltd
Publication Date:
2016
detail.hit.zdb_id:
2863457-3