In:
The Journal of Immunology, The American Association of Immunologists, Vol. 192, No. 1_Supplement ( 2014-05-01), p. 72.15-72.15
Abstract:
Frailty is a geriatric syndrome associated broadly with declines in health and function in older adults. Others have reported associations between frailty and changes in immune function including increased markers of inflammation and impaired response to influenza vaccination. In the current study we have studied a cohort of 118 older veterans with a median age of 81. They underwent Fried frailty testing and received seasonal trivalent inactivated influenza vaccine with blood drawn pre- and post-vaccination. Pre-vaccination serum inflammatory markers (IL-6, TNFR1, TNFR2), anti-flu cell mediated immunity, and pre- and post-hemagglutinin inhibition (HAI) titers were determined. As has been previously described, frailty correlated with age (r=0.32 p & lt;0.001) and serum IL-6 (r=0.41 p & lt;0.001). We extend the markers of inflammation to demonstrate that frailty also correlates with TNFR1 (r=0.32 p=0.001) and TNFR2 (r=0.38 p & lt;0.001). Contrary to a prior report we did not find a correlation between frailty and change in HAI titers after vaccination. We have an estimated power from our cohort size to detect a medium effect size of 0.23. It is possible frailty had a negative effect on vaccine response, but our sample size was too small to detect it although there was not even a trend to suggest that. Therefore, we did not find reduced antibody responses after influenza specifically in the frail veterans.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.192.Supp.72.15
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2014
detail.hit.zdb_id:
1475085-5
