In:
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, World Wide Journals
Abstract:
Circulatory assist devices need to be tested at various levels prior to human implantation. These include numerical simulations, lab and animal
testing, tissue computability prior to human trials that would scale in terms of complexity of indications and participant load. Mock circulatory loops though not ideal offer the best current equivalents of gold standard for such purposes in the in vitro domain. These could be very simple
hydraulic loops to complex hydraulic loop interface with computers. These need to replicate both right and left circulatory systems coupled with vascular compliances and resistances. It should recreate the perfusion rates and pressures that exist in normal systemic and pulmonary vasculature
for both normal and heart failure models. These rigs greatly reduce the device evaluation costs by mimicking nature though vasomotor responses in the normal human body may require complicated evaluation models to be deciphered in future by use of evolving technologies. Following
mechanical evaluation on the mock circulatory loop actual animal testing would give the experimental proof of concept. The basic requirements are that of a pump, ow channels, compliance chambers with monitoring of pressure and resistance changes using pressure and ow sensors. It serves
as a safe low cost training and evaluating platform. Virtual mock loop simulation tool can simulate the hemodynamics using a lumped-parameter model for systemic/pulmonary circulation characteristic inputs values for impedance, systolic and diastolic ventricular compliance, beat rate, and
blood volume and characteristics of the cardiac chambers and valves. VML contains several different lumped parameter models for selection and evaluation. It also stores and organizes data from different origins that makes comparison easier. For new total articial heart models the advantage
of a dual approach emerges with use of hybrid mechanical circulatory loop.
Type of Medium:
Online Resource
DOI:
10.36106/ijsr/5707085
Language:
English
Publisher:
World Wide Journals
Publication Date:
2022
