In:
Pain Physician, American Society of Interventional Pain Physicians, Vol. 7, No. 20;7 ( 2017-11-12), p. 641-647
Abstract:
Background: Major abdominal surgeries are associated with severe pain, which can affect
respiratory and cardiac functions if insufficiently treated; this increases postoperative morbidity. Objective: We aim at evaluating the efficacy of magnesium sulfate as an adjuvant to local anesthetic
in an ultrasound-guided transversus abdominis plane (TAP) block for postoperative analgesia in total abdominal hysterectomy.
Study Design: A prospective, randomized, double-blinded clinical trial. Setting: An academic medical center.
Methods: This study is registered at https://clinicaltrials.gov (no.: NCT02930707). This randomized, double-blinded clinical trial included 60 women undergoing total abdominal hysterectomy that were
divided into 2 groups (30 patients per group). Group I received a TAP block with 20 mL per side of 0.25% bupivacaine plus 2 mL magnesium sulphate 10% (200 mg). Group II received a TAP block
with 20 mL per side of 0.25% bupivacaine. Visual analog scale (VAS) scores, the time of the first analgesic request, total morphine consumption, and any side effects were assessed and recorded.
Results: The mean postoperative VAS score was significantly reduced in group I compared to group II in all of the time-points except after 10 hours. The mean time of the first request for rescue
analgesia was significantly prolonged in group I (15.67 hrs.) compared to group II (7.33 hrs.) (P 〈 0.001), and the mean total morphine consumption, over the first 24 hours postoperatively, was
significantly lower in group I (7.63 ± 2.93 mg) than in group II (16.20 ± 3.24 mg) (P 〈 0.001). No
significant difference in side effects was observed. Limitations: Sample size.
Conclusion: The addition of 200 mg of magnesium sulfate to bupivacaine in an ultrasound-guided TAP block significantly reduced postoperative opioid requirements, prolonged the duration of
analgesia, and reduced the VAS score in patients who underwent abdominal hysterectomy, without significant side effects.
Key words: Magnesium sulfate, TAP block, postoperative pain, total abdominal hysterectomy
Type of Medium:
Online Resource
ISSN:
2150-1149
,
1533-3159
DOI:
10.36076/ppj.2017.7.641
Language:
English
Publisher:
American Society of Interventional Pain Physicians
Publication Date:
2017
detail.hit.zdb_id:
2244163-3
