In:
Veterinary Sciences, MDPI AG, Vol. 9, No. 11 ( 2022-11-16), p. 636-
Abstract:
The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and ApcMin mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy.
Type of Medium:
Online Resource
ISSN:
2306-7381
DOI:
10.3390/vetsci9110636
Language:
English
Publisher:
MDPI AG
Publication Date:
2022
detail.hit.zdb_id:
2768971-2