In:
Non-Coding RNA, MDPI AG, Vol. 8, No. 6 ( 2022-12-07), p. 82-
Abstract:
Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between year of discovery and evolutionary conservation. This observation is specific to cancer over other diseases, implying a sampling bias in the selection of lncRNA candidates and casting doubt on the value of evolutionary metrics for the prioritisation of cancer-related lncRNAs.
Type of Medium:
Online Resource
ISSN:
2311-553X
DOI:
10.3390/ncrna8060082
Language:
English
Publisher:
MDPI AG
Publication Date:
2022
detail.hit.zdb_id:
2813993-8