In:
Molecules, MDPI AG, Vol. 22, No. 7 ( 2017-07-24), p. 1232-
Abstract:
Compound K is one of the active metabolites of Panaxnotoginseng saponins, which could attenuate the formation of atherosclerosis in mice modelsvia activating LXRα. We synthesized and evaluated a series of ginsenoside compound K derivatives modified with short chain fatty acids. All of the structures of this class of ginsenoside compound K derivative exhibited comparable or better biological activity than ginsenoside compound K. Especially structure 1 exhibited the best potency (cholesteryl ester content: 41.51%; expression of ABCA1 mRNA: 319%) and low cytotoxicity.
Type of Medium:
Online Resource
ISSN:
1420-3049
DOI:
10.3390/molecules22071232
Language:
English
Publisher:
MDPI AG
Publication Date:
2017
detail.hit.zdb_id:
2008644-1