In:
Healthcare, MDPI AG, Vol. 9, No. 1 ( 2021-01-15), p. 78-
Abstract:
COVID-19 is affecting many countries all around the world. Unfortunately, no treatment has already been approved for the management of patients infected by SARS-CoV-2. It seems that SARS-CoV-2 can induce the activation of an exaggerated immune response against itself according to different mechanisms that are not really well known. Inflammatory interleukins, such as IL-6 among others, play a central role in this uncontrolled immune response. There is a strong rational under ibrutinib use in in the treatment of immune-based diseases, such a as GVHD or RA. Ibrutinib achieves a reduction in the production of TNFα, IL1, IL-6 and Monocyte chemo-attractant protein-1 (MCP-1) by neutrophils and macrophages, that are key players in keeping the inflammatory process. We present our clinical experience about ibrutinib use in ARDS secondary to SARS-CoV-2 in a patient with chronic lymphocytic leukemia (CLL).
Type of Medium:
Online Resource
ISSN:
2227-9032
DOI:
10.3390/healthcare9010078
Language:
English
Publisher:
MDPI AG
Publication Date:
2021
detail.hit.zdb_id:
2721009-1