In:
Biomolecules, MDPI AG, Vol. 11, No. 4 ( 2021-04-12), p. 562-
Abstract:
Thrombin is a Na+-activated allosteric serine protease of the chymotrypsin family involved in coagulation, inflammation, cell protection, and apoptosis. Increasingly, the role of thrombin in the brain has been explored. Low concentrations of thrombin are neuroprotective, while high concentrations exert pathological effects. However, greater attention regarding the involvement of thrombin in normal and pathological processes in the central nervous system is warranted. In this review, we explore the mechanisms of thrombin action, localization, and functions in the central nervous system and describe the involvement of thrombin in stroke and intracerebral hemorrhage, neurodegenerative diseases, epilepsy, traumatic brain injury, and primary central nervous system tumors. We aim to comprehensively characterize the role of thrombin in neurological disease and injury.
Type of Medium:
Online Resource
ISSN:
2218-273X
DOI:
10.3390/biom11040562
Language:
English
Publisher:
MDPI AG
Publication Date:
2021
detail.hit.zdb_id:
2701262-1
