In:
Frontiers in Nutrition, Frontiers Media SA, Vol. 9 ( 2022-12-8)
Abstract:
Inflammatory bowel diseases (IBD) are chronic immune-mediated diseases, mainly represented by Crohn's disease (CD) and ulcerative colitis (UC). Several environmental factors have been proposed to contribute to disease pathogenesis, amongst which are metals. These can affect the immune system and may be associated with IBD. The aim of the present cross-sectional study was to investigate blood levels of metals in IBD patients and to examine possible associations with clinical and inflammatory disease markers. Methods In total, 76 CD patients, 39 UC patients and 38 healthy controls were included. Blood and stool samples were collected. Metals were quantified in plasma samples using inductively coupled plasma mass spectrometry. Results There were more abnormalities of circulating metals in CD than in UC when compared to healthy controls. CD: Concentrations of the essential trace elements zinc and selenium were lower in CD patients than the controls. Chromium was negatively associated with serum IL-6 (Beta: −3.558, p = 0.011), and caesium with fecal calprotectin (Beta: −0.481, p = 0.038) and serum IL-10 (Beta: −1.912, p = 0.050). In contrast, copper was positively associated with C-reactive protein (Beta: 2.548 × 10 2 , p = 0.033). UC: In UC, a negative association of iron with serum myeloperoxidase levels (Beta: −1.270 × 10 3 , p = 0.044) was detected. Thallium, a hazardous metal, however, was positively associated with disease activity (Beta: 3.899, p = & lt; 0.01). Conclusion In conclusion, our study offers new insights into the relations of metals with IBD. Further research should focus on the evaluation of the above associations and potential underlying mechanisms.
Type of Medium:
Online Resource
ISSN:
2296-861X
DOI:
10.3389/fnut.2022.997356
DOI:
10.3389/fnut.2022.997356.s001
DOI:
10.3389/fnut.2022.997356.s002
DOI:
10.3389/fnut.2022.997356.s003
DOI:
10.3389/fnut.2022.997356.s004
DOI:
10.3389/fnut.2022.997356.s005
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2776676-7
