In:
Frontiers in Chemistry, Frontiers Media SA, Vol. 10 ( 2022-3-31)
Abstract:
The present study discusses comparative structural features of fourteen multicomponent solids of two non-steroidal anti-inflammatory drugs, Niflumic and Mefenamic acids, with amine and pyridine-based coformers. All the solids were structurally characterized through PXRD, SCXRD, DSC, and the monophasic nature of some of the solids was established through Rietveld refinement. The solid forms include salt, cocrystal, hydrate, and solvate. Except for two, all the solids reported here showed relatively higher solubility compared to the acids. The difference in p K a and similarity in structural features of both the molecules enabled us to study the effect of Δp K a on crystallization outcome systematically. The structures of all the solids are described through acid-pyridine synthon perspective.
Type of Medium:
Online Resource
ISSN:
2296-2646
DOI:
10.3389/fchem.2022.729608
DOI:
10.3389/fchem.2022.729608.s001
DOI:
10.3389/fchem.2022.729608.s002
DOI:
10.3389/fchem.2022.729608.s003
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2711776-5