In:
Research Journal of Chemistry and Environment, World Researchers Associations, Vol. 27`, No. 9 ( 2023-08-15), p. 75-82
Abstract:
In India, Momordica charantia Linn. is utilized in juices, health supplements and colouring agents. The aim of the current study is to analyze phytoligands by utilizing gas chromatography mass spectroscopy of aqueous seed extract of Momordica charantia Linn (MCA). The MCA was prepared by macerating the powdered seeds for 72 hrs followed by filtration and lyophilization followed by an in vitro α-glucosidase inhibitory activity. MCA was the potent inhibitor of α-glucosidase with IC50 value 73.75± 0.05 μg/ml. The analysis through GC-MS investigated 60 phytoconstituents which were validated using Schrodinger suite version 2020-3 against α-glucosidase (PDB ID- 5NN5). As per docking results, the existing phytochemicals azetidin-2-one 3,3-dimethyl-4-(1-aminoethyl)-, alpha-l-rhamnopyranose, piperidine, 3-methyl-, 1,4-Dioxane-2,5-dione,3,6-dimethyl and citronellol epoxide (R or S) from MCA, got the highest d-score of -7.230, -5.918, -5.643, -5.312 and -5.185 kcal/mol and could be promising antidiabetic drug candidates.
Type of Medium:
Online Resource
ISSN:
0972-0626
,
2278-4527
DOI:
10.25303/2709rjce075082
Language:
Unknown
Publisher:
World Researchers Associations
Publication Date:
2023
