In:
VNU Journal of Science: Natural Sciences and Technology, Vietnam National University Journal of Science, Vol. 33, No. 4 ( 2017-11-28)
Abstract:
The pyridinocrownophane derivatives containing 2,6-diaryl-γ-arylpyridine subunit and the aza-14-crown-4 ether ring have been exhibit high cytotoxicity on several tumor cell lines such as Hep- G2, MCF7, FL, RD, Lu. This study continues to develop method of synthesis of new γ-(fur-2-yl)pyridinoaza-14-crown-4-ether (2), γ-(naphthalen-1-yl)pyridinoaza-14-crown-4-ether (3), γ-(thien-2-yl)pyridinoaza-17-crown-5-ether (4) and γ-(2-pyridino)pyridinoaza-17-crown-5-ether (5) based on the 1,5-bis- (2-acetylphenoxy) -3- -oxapentane (1a) and 1,8-bis- (2-acetylphenoxy) -36-dioxaoctane (1b). The structure of these derivatives has determined by 1 H NMR, HPLC-MS.
Type of Medium:
Online Resource
ISSN:
2588-1140
,
2588-1140
DOI:
10.25073/2588-1140/vnunst.4479
Language:
Unknown
Publisher:
Vietnam National University Journal of Science
Publication Date:
2017