In:
Diabetes, American Diabetes Association, Vol. 31, No. 2 ( 1982-02-01), p. 119-121
Abstract:
The effect of tolbutamide on somatostatin release from the isolated perfused stomach was investigated in both normal and streptozotocin-diabetic rats. Tolbutamide (10, 100, and 1000 μg/ml) evoked a significant and dose-dependent increase in gastric somatostatin release. The tolbutamide (100 μg/ml)-induced gastric somatostatin secretion was not influenced by differences in glucose concentration (1.5, 5.5, and 16.5 mM) throughout the perfusion period. Tolbutamide (100 microgram/ml)-induced gastric somatostatin release in streptozotocin-diabetic rats was significantly higher than in normal rats. Thus, tolbutamide is a potent secretagogue for gastric somatostatin secretion, and this effect is more prominent in diabetic animals.
Type of Medium:
Online Resource
ISSN:
0012-1797
,
1939-327X
DOI:
10.2337/diab.31.2.119
Language:
English
Publisher:
American Diabetes Association
Publication Date:
1982
detail.hit.zdb_id:
1501252-9