In:
Diabetes, American Diabetes Association, Vol. 73, No. Supplement_1 ( 2024-06-14)
Abstract:
Introduction & Objective: Prior to T2D, patients experience increased infections, yet no pathways account for this immune/endocrine system cross-talk. We aimed to identify metabolites that link pathogens to T2D. Methods: Using plasma from 4,424 adults (61 ±9 y; 53% female), taxonomic classification was conducted on reads from sequencing that aligned with a microbial reference panel, and metabolites quantified. Incident T2D (ADA 2003 criteria) was assessed over ~18 y. A cox-proportional hazard model identified baseline microbes as ‘variables of importance’ to incident T2D, with a penalty function to minimize sparse data bias. Metabolome-wide associations identified metabolites shared between T2D-related microbes at baseline, and incident T2D. All models adjusted for age, gender, race/ethnicity, education, and AHA’s Life’s Simple 8 score. Results: Total microbes differed by race/ethnicity (X2= 30.4, df = 9, P= 3.8*10-4), but not any other covariates (all P & gt;.05). Incident T2D was associated with 2 microbes: Rahnella (HR=1.90 (1.09-3.30), P=.02) and Plasmodium falciparum (HR=1.34 (1.05-1.73), P=.02). 23 metabolites were associated with incident T2D (P & lt;.05 after an FDR-correction) and at least one of these microbes (P & lt;.05; Fig). Conclusions: These analyses indicate molecules linking exposure to, and / or continued presence in the plasma of, infectious microbes, and increased risk of T2D. Disclosure A. Wood: Research Support; Beef Checkoff. Consultant; Lundquist. M.O. Goodarzi: Advisory Panel; Nestlé Health Science, Organon. Z. Chen: None. X. Guo: None. S.S. Rich: None. C.B. Clish: None. R.E. Gerszten: None. J.I. Rotter: None. K. Taylor: None. Funding USDA/ARS cooperative agreement (#58-3092-5-001). Advancing Translational Sciences (UL1TR001420, UL1TR001881).
Type of Medium:
Online Resource
ISSN:
0012-1797
DOI:
10.2337/db24-1994-LB
Language:
English
Publisher:
American Diabetes Association
Publication Date:
2024
detail.hit.zdb_id:
1501252-9
