In:
IUPHAR/BPS Guide to Pharmacology CITE, Edinburgh University Library, Vol. 2019, No. 4 ( 2019-09-16)
Abstract:
Adhesion GPCRs are structurally identified on the basis of a large extracellular region, similar to the Class B GPCR, but which is linked to the 7TM region by a GPCR autoproteolysis-inducing (GAIN) domain [8] containing a GPCR proteolytic site. The N-terminus often shares structural homology with adhesive domains (e.g. cadherins, immunolobulin, lectins) facilitating inter- and matricellular interactions and leading to the term adhesion GPCR [82, 332] . Several receptors have been suggested to function as mechanosensors [254, 234, 315, 32]. The nomenclature of these receptors was revised in 2015 as recommended by NC-IUPHAR and the Adhesion GPCR Consortium [100] .
Type of Medium:
Online Resource
ISSN:
2633-1020
DOI:
10.2218/gtopdb/F17/2019.4
Language:
Unknown
Publisher:
Edinburgh University Library
Publication Date:
2019