In:
Nanomedicine, Future Medicine Ltd, Vol. 11, No. 8 ( 2016-04), p. 941-957
Abstract:
The human placenta is a multifunctional organ constituting the barrier between maternal and fetal tissues. Nanoparticles can cross the placental barrier, and there is increasing evidence that the extent of transfer is dependent on particle characteristics and functionalization. While translocated particles may pose risks to the growing fetus particles may also be engineered to enable new particle-based therapies in pregnancy. In both cases, a comprehensive understanding of nanoparticle uptake, accumulation and translocation is indispensable and requires predictive placental transfer models. We examine and evaluate the current literature to draw first conclusions on the possibility to steer translocation of nanoparticles. In addition, we discuss if current placental models are suitable for nanoparticle transfer studies and suggest strategies to improve their predictability.
Type of Medium:
Online Resource
ISSN:
1743-5889
,
1748-6963
DOI:
10.2217/nnm-2015-0012
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2016
SSG:
15,3
