In:
Current Cancer Drug Targets, Bentham Science Publishers Ltd., Vol. 18, No. 7 ( 2018-07-31), p. 618-628
Abstract:
Background: There is emerging data suggesting that the non-coding RNA (microRNA
193a or miR-193a) plays key roles in different types of cancers. Objective: This review aims to investigate the functional significance of miR-193a in different cancers
according to the information of literature. Method: All the literature concerning miR-193a in cancer in PubMed are analysed. Results: Several studies proved the association of miR-193a expression patterns with cancer’s
stages, grades, response to the chemotherapy and even patient survival. Also, miR-193a can be used to differentiate some types of cancer. In cancer, miR-193a can act as a tumour suppressor gene or as
an oncogene. Till now, several genetic factors (MAX, RXR α, XB130, P63, P73, AEG-1, HIFs, EGFR, Drosha, DGCR8, Dicer) and epigenetic factors (DNA methylation and long non-coding
RNAs) were predicted to control miR-193a expression. They have fundamental effects on its biological behaviour in different types of cancers. Conclusion: miR-193a has significant roles in cancer and can be targeted in the future for cancer
therapy by better understanding of the factors that control its biological behaviour.
Type of Medium:
Online Resource
ISSN:
1568-0096
DOI:
10.2174/1568009618666180308105727
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2018
SSG:
15,3
