In:
Current Pharmaceutical Design, Bentham Science Publishers Ltd., Vol. 28, No. 22 ( 2022-06), p. 1843-1853
Abstract:
Various anticancer drugs are effective therapeutic agents for cancer treatment; however,
they cause severe toxicity in body organs. Cardiotoxicity is one of the most critical side effects of these drugs. Based on various findings, turmeric extract has positive effects on cardiac cells. Objective: This study aims to evaluate how curcumin, as the main component of turmeric, may affect chemotherapy- induced cardiotoxicity. Method: A database search was performed up to April 2021 using “curcumin OR turmeric OR Curcuma longa”
and “chemotherapy-induced cardiac disease”, including their equivalents and similar terms. After screening the total articles obtained from the electronic databases, 25 relevant articles were included in this systematic review. Results: The studies demonstrate lower body weight and increased mortality rates due to doxorubicin administration.
Besides, cancer therapeutic agents induced various morphological and biochemical abnormalities compared to the non-treated groups. Based on most of the obtained results, curcumin at nontoxic doses can
protect the cardiac cells mainly through modulating antioxidant capacity, regulation of cell death, and antiinflammatory effects. Nevertheless, according to a minority of findings, curcumin increases the susceptibility of
the rat cardiomyoblast cell line (H9C2) to apoptosis triggered by doxorubicin. Conclusion: According to most nonclinical studies, curcumin could potentially have cardioprotective effects
against chemotherapy-induced cardiotoxicity. However, based on limited, contradictory findings demonstrating the function of curcumin in potentiating doxorubicin-induced cardiotoxicity, well-designed studies are needed
to evaluate the safety and effectiveness of treatment with new formulations of this compound during cancer therapy.
Type of Medium:
Online Resource
ISSN:
1381-6128
DOI:
10.2174/1381612828666220513125312
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2022
SSG:
15,3
