In:
Current Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 31 ( 2024-06-27)
Abstract:
Methamphetamine (MA) is well recognized as a psychostimulant
that can cause neurotoxicity and neurodegeneration, which is associated with cognitive decline, has been confirmed experimentally. Objective: The research aimed to investigate the neuroprotective properties of europinidin
(Eu) in rodents affected by methamphetamine (MA)-induced cognitive impairments and hippocampal alterations. This was achieved by inhibiting lipid peroxidation
and pro-inflammatory markers. Methods: Rats were exposed to cognitive impairment produced by MA. The Morris water
maze (MWM) is utilized for evaluating behavioral parameters. Tests were conducted on malondialdehyde (MDA), catalase (CAT), interleukins-1β (IL-1β), reduced glutathione
(GSH), tumor necrosis factor-α (TNF-α), superoxide dismutase (SOD), and the expression of neurotransmitters (Norepinephrine [NE], dopamine [DA] , glutamate, and
gamma-aminobutyric acid [GABA] ) as well as cAMP response element-binding protein
(CREB), IL-6, brain-derived neurotrophic factor (BDNF), and caspase 3 proteins. An investigation was carried out using docking methodology to ascertain whether Eu interacts
with relevant molecular targets. Results: Significant decline in the transfer latency and there were significant changes in
the amount of SOD, GSH, CAT, and MDA and alterations in levels of IL-6, IL-1β, CREB, TNF-α, BDNF, and Caspase 3 proteins expression, as well as considerably alterations
in level of neurotransmitters (NE, DA, Glutamate, and GABA) were observed in the Eu-treated rats compared to the MA-induced rats. Eu had a favorable affinity towards
BDNF with docking scores of -9.486 kcal/mol. Conclusion: The experiment found that administering Eu to rats improved cognitive
abilities by changing antioxidant enzymes, reducing cytokines, and modifying neurotransmitter levels, compared to rats in the control group treated with MA.
Type of Medium:
Online Resource
ISSN:
0929-8673
DOI:
10.2174/0109298673307759240614114201
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2024
detail.hit.zdb_id:
1319315-6
SSG:
15,3
