In:
Journal of Endocrinology, Bioscientifica, Vol. 134, No. 1 ( 1992-07), p. 73-76
Abstract:
The possible role of cyclic adenosine 3′,5′-monophosphate (cAMP) in mediating the action of steroid hormones was investigated using the rat lung. Male rats were adrenalectomized and treated with olive oil, dexamethasone, corticosterone, deoxycorticosterone (DOC) or progesterone. At the end of 10 days, 100 μg isoprenaline/kg was injected intraperitoneally 5 min before the animals were killed to stimulate cAMP production. Adrenalectomy significantly decreased cAMP levels in the rat lung. Dexamethasone and corticosterone pretreatment reversed the effect of adrenalectomy whereas progesterone pretreatment but not DOC pretreatment significantly decreased lung cAMP levels. Cyclic AMP levels in normal female rats, whether pregnant or not, were not significantly different from those in male rats. We concluded that the absence of glucocorticoid, as after adrenalectomy, decreased the cAMP levels in rat lungs and that this could be reversed by either dexamethasone or corticosterone replacement. Progesterone reduced the cAMP content in rat lungs by acting as a glucocorticoid antagonist or by acting directly via progesterone receptors. Journal of Endocrinology (1992) 134, 73–76
Type of Medium:
Online Resource
ISSN:
0022-0795
,
1479-6805
DOI:
10.1677/joe.0.1340073
Language:
Unknown
Publisher:
Bioscientifica
Publication Date:
1992
detail.hit.zdb_id:
1474892-7
