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    Neonatal Encephalopathy: Treatment With Hypothermia
    American Academy of Pediatrics (AAP) ; 2010
    In:  NeoReviews Vol. 11, No. 2 ( 2010-02-01), p. e85-e92
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    In: NeoReviews, American Academy of Pediatrics (AAP), Vol. 11, No. 2 ( 2010-02-01), p. e85-e92
    Abstract: This article evaluates the pathophysiology of brain injury from hypoxia-ischemia in preclinical models and the role of hypothermia as neuroprotection following this injury. The diagnosis of encephalopathy due to hypoxia and ischemia in term and near-term infants following acute perinatal asphyxia is clarified. The neuroprotective effect of hypothermia when initiated before 6 hours of age for 72 hours to a depth of 33.0°C to 34.0°C in reducing death and disability is reviewed. Therapeutic hypothermia is safe and effective when applied according to published clinical trial protocols, although gaps in knowledge still remain.
    Type of Medium: Online Resource
    ISSN: 1526-9906
    URL: Article
    DOI: 10.1542/neo.11-2-e85
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 2010
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