In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 76, No. 1 ( 1974-05), p. 117-126
Abstract:
The concentrations of oestrone (Oe 1 ) and oestradiol (Oe 2 ) in adrenal venous and peripheral plasma (inferior vena cava, aorta and/or antecubital vein) were measured by radioimmunoassay in 8 patients in whom an adrenal disorder was suspected (group A) and 5 patients in whom an adrenal disorder was proven (group B). In group A, 6 patients had higher Oe 1 concentrations in adrenal than in peripheral plasma, while 5 patients had higher Oe 2 concentrations in adrenal venous plasma. In group B, in 3 of 4 patients with primary aldosteronism secondary to an adrenocortical adenoma, both Oe 1 and Oe 2 concentrations in the adrenal venous plasma from the side of the adenoma were greater than in peripheral plasma. A patient with Cushing's disease showed a similar gradient for Oe1 but not Oe2. The results are consistent with the following conclusions: 1) Both Oe 1 and Oe 2 are secreted from the adrenal in neoplastic and non-neoplastic disorders in detectable but small amounts. 2) Estimates of maximal adrenal secretion rates in 3 male patients indicate that the adrenal contribution was less than 4 % (Oe 1 ) and less than 2 % (Oe 2 ), of reported blood production rates of oestrogens in normal men.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.0760117
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1974
detail.hit.zdb_id:
1183856-5
detail.hit.zdb_id:
1485160-X
