In:
EMBO reports, EMBO, Vol. 21, No. 1 ( 2020-01-07)
Abstract:
image 2‐cell‐like cells share some metabolic features with the early mouse embryo, indicating a shift of the metabolic programme during 2‐cell‐like cell reprogramming. 2‐cell‐like cells exhibit decreased glycolytic and respiratory activity compared with ES cells. 2‐cell‐like cells do not upregulate oxygen consumption upon acute supplementation of pyruvate or of respiration‐uncoupling agents, suggesting diminished respiratory capacity. Metabolites such as sodium acetate, sodium l ‐lactate or d ‐ribose can induce the emergence of Zscan4 + and 2‐cell‐like cells in culture.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.201948354
Language:
English
Publisher:
EMBO
Publication Date:
2020
detail.hit.zdb_id:
2025376-X
SSG:
12