In:
EMBO reports, EMBO, Vol. 21, No. 1 ( 2020-01-07)
Abstract:
image SAMHD 1, a well‐studied HIV ‐1 restriction factor, counteracts also the hand‐foot‐and‐mouth disease pathogen EV71. Upon infection, the E3 ligase TRIM 21 is up‐regulated in an IFN ‐dependent manner to induce SAMHD 1 degradation and to relieve virus restriction. Host restriction factor SAMHD 1 inhibits the replication of hand‐foot‐and‐mouth disease virus EV71. TRIM 21 specifically interacts and degrades SAMHD 1 through K48‐ubiquitination and proteasomal degradation. TRIM 21 is up‐regulated upon EV71 infection in an IFN ‐dependent manner. TRIM 21‐mediated degradation of SAMHD 1 also affects HIV ‐1 restriction and increases interferon production.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.201847528
Language:
English
Publisher:
EMBO
Publication Date:
2020
detail.hit.zdb_id:
2025376-X
SSG:
12