In:
The EMBO Journal, EMBO, Vol. 41, No. 23 ( 2022-12)
Abstract:
image This study reports a non‐catalytic tumorigenic role for serine biosynthesis enzyme phosphoglycerate dehydrogenase (PHGDH) in enhancing mitochondrial translation and respiratory metabolism in cancer cells, suggesting a new target for tumour progression. PHGDH localizes to the inner mitochondrial membrane in human liver cancer cells and patient tissues. PHGDH promotes translation of mtDNA‐encoded ETC proteins in catalytic activity‐independent manner. PHGDH forms a complex with mitochondrial translation factors ANT2 and mtEFG2, enhancing mtRRF interaction and mitoribosome recycling. PHGDH increases tumour growth in mice translation‐dependently by elevating respiratory metabolism.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2022111550
Language:
English
Publisher:
EMBO
Publication Date:
2022
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12