GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
back to result list
  • 1
    Online Resource
    Online Resource
    BNIP3 contributes to the glutamine-driven aggressive behavior of melanoma cells
    Walter de Gruyter GmbH ; 2019
    In:  Biological Chemistry Vol. 400, No. 2 ( 2019-01-28), p. 187-193
    Details
    In: Biological Chemistry, Walter de Gruyter GmbH, Vol. 400, No. 2 ( 2019-01-28), p. 187-193
    Abstract: Aerobic glycolysis (‘Warburg effect’) is used by cancer cells to fuel tumor growth. Interestingly, metastatic melanoma cells rely on glutaminolysis rather than aerobic glycolysis for their bioenergetic needs through the tricarboxylic acid (TCA) cycle. Here, we compared the effects of glucose or glutamine on melanoma cell proliferation, migration and oxidative phosphorylation in vitro . We found that glutamine-driven melanoma cell’s aggressive traits positively correlated with increased expression of HIF1α and its pro-autophagic target BNIP3. BNIP3 silencing reduced glutamine-mediated effects on melanoma cell growth, migration and bioenergetics. Hence, BNIP3 is a vital component of the mitochondria quality control required for glutamine-driven melanoma aggressiveness.
    Type of Medium: Online Resource
    ISSN: 1437-4315 , 1431-6730
    URL: Article
    DOI: 10.1515/hsz-2018-0208
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2019
    detail.hit.zdb_id: 1466062-3
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...