In:
Hormone Molecular Biology and Clinical Investigation, Walter de Gruyter GmbH, Vol. 44, No. 2 ( 2023-06-30), p. 219-227
Abstract:
– Brown adipose tissue is a therapeutic target to combat obesity and its comorbidities by modulating the batokines profile and activating thermogenic activity. – FGF21 is released by BAT during thermogenesis and exerts beneficial effects on the cardiovascular system. – VEGF-A is the batokine that regulates BAT by autocrine mechanisms and promotes the maintenance of angiogenesis and thermogenesis. – BMP8 is expressed during thermogenesis and promotes the regulation of energy metabolism between the hypothalamus and the BAT. – NRG-4 is a batokine that belongs to the epidermal growth factor family members and exerts beneficial effects on the liver and insulin resistance. – Myostatin is a batokine harmful to skeletal muscle, and BAT activation is a significant target to avoid myostatin’s deleterious effects on muscle bioenergetics. – IL-6 improves glucose metabolism in adipocytes and the liver and acts in the maintenance of thermogenesis. – Batokines represent promising therapeutic targets for treating obesity and its comorbidities.
Type of Medium:
Online Resource
ISSN:
1868-1891
DOI:
10.1515/hmbci-2022-0044
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2023
detail.hit.zdb_id:
2536635-X
