In:
Green Processing and Synthesis, Walter de Gruyter GmbH, Vol. 5, No. 6 ( 2016-01-1)
Abstract:
In this study, in order to enhance the aqueous solubility and to overcome the limitation of curcumin (Cur) in free form, as well as to develop a carrier for transdermal delivery of hydrophobic pharmaceutical agents such as Cur, a sonicated synthetic process of nanocurcumin (nCur) in thermally responsive Chitosan-g-Pluronic (CP) copolymer is disclosed herein. The use of CP copolymer solution as a dispersant medium is a very attractive method to avoid the use of toxic organic solvent and non-biocompatible surfactant. The obtained Cur nanoparticles had a fairly narrow distribution of 8–23 nm. nCur-dispersed CP solution showed good stability with no change in color characteristic and no phase separation after 1 month of storage. Rheological characterization of CP hydrogels had indicated sol-gel transition at the same temperature (35°C). Interestingly, the rate of Cur release for this system can be conveniently modulated as transdermal drug delivery.
Type of Medium:
Online Resource
ISSN:
2191-9550
,
2191-9542
DOI:
10.1515/gps-2016-0062
Language:
Unknown
Publisher:
Walter de Gruyter GmbH
Publication Date:
2016
detail.hit.zdb_id:
2645923-1